When it comes to taking long-haul flights in economy (which let's face it, almost 99.9% of us fly economy), there is no real way to be completely at ease BUT there is plenty you can do to make it as enjoyable as possible. The number one tip I have is to be prepared long in advance. There's nothing like stress to set off your trip on the wrong foot. I tend to pack a full few weeks in advance, and while I don't recommend this necessarily, it is good to have all your ducks in a row a few days before your flight.
The Creative Adventurer is a travel blog with guides to help you get the most meaningful and unique experiences out of your wanderings.